Wednesday, September 23, 2009

Hypoglycemia and Cancer tumor;To Maintaining Low Blood Sugar as a New Cancer Treatment

To Maintaining Low Blood Sugar as a New Cancer Treatment

Many people believe that vegetarian diet is good for cancer. And many scientist tried to find out certain factor which is important thing as cancer treatment from vegetables and fruits. But, remarkable factor is not revealed in the world. So this writing is for the discovery of the factor. And perhaps side effect of surfeit of vegetable is the factor. For determine whether low blood sugar which is side effect of surfeit of vegetable is the main factor or have no relation to death of cancer, amount of sugar essential and total of sugar supply are partially calculated.

A human cell has about 2.8billion(1) base pairs(or about 5.6 billion base) and 2.8billion base pairs have 11.2 billion deoxyriboses as a DNA back bone(2). Deoxyribose and glucose are sugar. So glucose maybe used as a raw material of DNA back bone. And for 1.12e+10 deoxyriboses, 3.3477e-12 g glucose may be essential as a raw material of deoxyriboses.

The number of cancer cells is about 2000/mm^2(3) and the density of microvessel is about 200(count)/mm^2(3) and the average diameter of microvessels is about 10μm(). One microvessel of 200 microvessels in 1cm length of tumor is surrounded by 4472 cancer cells.

2000/mm^2 times sqrt{2000/mm^2} times 10mm div 200/mm^2 approx 4472.136 The concept of a cancer cell is a point. And the concept of a microvessel is a line.

Cancer cells which surround one microvessel must needs 1.4971e-8 g glucose per 1cm as the raw material of the deoxyriboses.

The blood flow velocity is about 0.49 mm/sec in capillaries(4). If the average blood sugar level is 100mg/dl, total amount of glucose which passes through a microvessel of10μm diameter is 3.323376e-6g/Day.

1.4971e-8 g is about 0.45% of 3.323376e-6g. But it's not calculated that how percent of 3.323376e-6g glucose is absorbed by 4472 cancer cells. And it's sure that 4472 cancer cells consume more glucose than 1.4971e-8 g.

For calculating the percent of the absorption, osmotic pressure and diffusion velocity must be considered. And it must not ignored that the convection must be limited among the cancer cells.

Most cancer cells starve(die) and 4% of survived cells induce KRAS Pathway Mutations in 9mg/dl glucose(5). This means that low blood sugar induce the necrosis of cancer cells. Besides, the density of microvessels in tumor have relation to cancer returns(6).

Under 70mg/dl glucose in micorvessels may reach under 9mg/dl glucose among cancer cells. One microvessel manages about 40μm from itself. 40μm is 8 times of radius of microvessel of 10μm diameter. Cancer cell which closes to microvessel will absorbs more sugar than enough so another cell may absorbs less sugar than essential amount. Besides, the glucose concentration in a micorvessel of the cancer tumor will be getting lower as blood flows(figure1). Figure1 explains that why huge tumor have disadvantages in low blood sugar level.

The calculation is not completed. But if someone completes this calculation, every things will be sure. Or if someone who has cancer maintains low blood sugar level(under 70mg/dl), we can know the relation between blood sugar level and cancer growth.

At last, the change of dietary has relation to avoid cancer death(7) no matter that the relation are strong or not. The important thing is that perhaps the induced low blood sugar by vegetable based diets are the main reason to avoid cancer death. The concentration of amino acid also needs to consider.

The purpose of this writing is to informing that to maintaining low glucose may be better treatment than chemotherapy. All of cancer patients have to know that perhaps to maintaining low blood glucose(always under 70mg/dl) is enough good as a new cancer treatment.

Figure1. Conception of glucose loss when blood flows : As blood flows, concentration of glucose is getting lower as cancer cell absorb much glucose.

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2. Levene P, (01 December 1919). "The structure of yeast nucleic acid". J Biol Chem 40 (2): 415–24.

3. Tsuyotoshi Tsuji, Yoshihiro Sasaki, Masanori Tanaka, et al: Microvessel Morphology and Vascular Endothelial Growth Factor Expression in Human Colonic Carcinoma With or Without Metastasis. Lab Invest 2002, 82:555–562

4. M.Stucker, V. Baier, T. Reuther, et al. Capillary Blood Cell Velocity in human skin capillaries located perpendiculary to the skin surface: Measured by a New Laser doppler anemometer. Microvascular research 52, 188-192(1996)

5. Jihye Yun, Carlo Rago, Ian Cheong, et al. Glucose Deprivation Contributes to the Development of KRAS Pathway Mutations in Tumor Cells. Science DOI: 10.1126/science.1174229

6. Noel Weidner. Intratumor Microvessel Density as a Prognostic Factor in Cancer. American Journal ofPathology, Vol. 147, No. 1, July 1995

7. WC Willett: Diet, nutrition, and avoidable cancer. Environmental Health Perspectives 103:165-170, 1995 (suppl 8)

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